Aquadetrim drops for oral administration 15 thousand IU/ml 10 ml (Akrikhin)

Aquadetrim is a medication that is responsible for the normal metabolism of phosphorus and calcium.

• Pharmacology and pharmacodynamics
• Why do they drink Aquadetrim?
• How to take Aquadetrim drops correctly
• Contraindications and adverse reactions
• How to give Akvadetrim to a child
• How to give Akvadetrim to a baby correctly
• Can pregnant women take Aquadetrim?
• Where should Aquadetrim be stored?
• What is the best replacement for Aquadetrim?
• special instructions
• How much does Aquadetrim cost?

Pharmacology and pharmacodynamics

The medicine allows you to stabilize the metabolism of phosphorus and calcium in the body.

Vitamin D3 is known to everyone as an antirachitic element. It plays one of the main roles - it takes part in the metabolism of calcium and phosphates, which improves skeletal growth.

This vitamin is very important in the absorption of phosphates and calcium in the digestive system and the transport of salts.

If the child’s body receives an insufficient amount of the vitamin, its absorption will be impaired, and if the person is exposed to sunlight for a short time, this can lead to rickets in the child, and bone tissue can soften in an adult.

Aquadetrim - instructions for use

Pharmacological properties

Pharmacodynamics

Vitamin D3 is a natural form of vitamin D that is formed in humans in the skin under the influence of sunlight. Compared to vitamin D2, it is characterized by 25% higher activity.

Vitamin D binds to the specific vitamin D receptor (VDR), which regulates the expression of many genes, including the ion channel genes TRPV6 (ensures the absorption of calcium in the intestine), CALB1 (calbindin; ensures the transport of calcium into the bloodstream), BGLAP (osteocalcin; ensures bone mineralization tissue and calcium homeostasis), SPP1 (osteopontin; regulates osteoclast migration), REN (renin; ensures regulation of blood pressure, being a key element of the renin-angiotensin-aldosterone regulation system), IGFBP (insulin-like growth factor binding protein; enhances the action of insulin-like growth factor) , FGF23 and FGFR23 (fibroblast growth factor 23; regulate the levels of calcium, phosphate anion, processes of cell division of fibroblasts), TGFB1 (transforming growth factor beta-1; regulates the processes of cell division and differentiation of osteocytes, chondrocytes, fibroblasts and keratinocytes), LRP2 ( LDL receptor-related protein 2; mediates endocytosis of low-density lipoproteins), INSR (insulin receptor; ensures the effects of insulin on any cell type).

Vitamin D3 is an active antirachitic factor. The most important function of vitamin D3 is to regulate calcium and phosphate metabolism, which promotes proper mineralization and skeletal growth.

Colecalciferol plays a significant role in the absorption of calcium and phosphates in the intestine, in the transport of mineral salts and in the process of bone calcification, and also regulates the excretion of calcium and phosphates by the kidneys. The concentration of calcium ions in the blood determines the maintenance of muscle tone of skeletal muscles, myocardial function, promotes nervous stimulation, and regulates the process of blood clotting.

Lack of vitamin D in food, impaired absorption, calcium deficiency, as well as insufficient exposure to the sun during the period of rapid growth of a child leads to rickets, in adults - to osteomalacia, pregnant women may experience symptoms of tetany, disruption of the calcification processes of the bones of newborns. An increased need for vitamin D occurs in women during menopause, as they often develop osteoporosis due to hormonal imbalances. Vitamin D has a number of so-called. extraskeletal effects. Vitamin D is involved in the functioning of the immune system by modulating cytokine levels and regulating the division of T-helper lymphocytes and the differentiation of B-lymphocytes. A number of studies have noted a decrease in the incidence of respiratory tract infections with vitamin D supplementation.

It has been shown that vitamin D is an important part of the homeostasis of the immune system: it prevents autoimmune diseases (type 1 diabetes mellitus, multiple sclerosis, rheumatoid arthritis, inflammatory bowel diseases, etc.). Vitamin D has antiproliferative and differentiation effects, which determine the oncoprotective effect of vitamin D. Noted that the incidence of certain tumors (breast cancer, colon cancer) increases against the background of low levels of vitamin D in the blood.

Vitamin D is involved in the regulation of carbohydrate and fat metabolism by influencing the synthesis of IRS1 (insulin receptor substrate 1; participates in the intracellular pathways of the insulin receptor signal), IGF (insulin-like growth factor; regulates the balance of adipose and muscle tissue), PPAR-δ (activated receptor peroxisome proliferators, type δ; helps process excess cholesterol). According to epidemiological studies, vitamin D deficiency is associated with the risk of metabolic disorders (metabolic syndrome and type 2 diabetes mellitus). Vitamin D receptors and metabolizing enzymes are expressed in arterial vessels, the heart, and virtually all cells and tissues relevant to the pathogenesis of cardiovascular disease. Animal models show anti-atherosclerotic effects, renin suppression and prevention of myocardial damage, etc. Low levels of vitamin D in humans are associated with unfavorable risk factors for cardiovascular pathology, such as diabetes mellitus, dyslipidemia, arterial hypertension, and are associated with the risk of cardiovascular accidents incl. strokes.

Studies in experimental models of Alzheimer's disease showed that vitamin D3 reduced amyloid accumulation in the brain and improved cognitive function. Non-interventional human studies have shown that the incidence of dementia and Alzheimer's disease increases with low vitamin D levels and low dietary intake of vitamin D. Cognitive function and the incidence of Alzheimer's disease have been impaired with low vitamin D levels.

Pharmacokinetics

An aqueous solution of vitamin D3 is absorbed better than an oil solution. In premature babies, there is insufficient formation and flow of bile into the intestines, which interferes with the absorption of vitamins in the form of oil solutions.

After oral administration, colecalciferol is absorbed in the small intestine. Metabolized in the liver and kidneys. The half-life of colecalciferol from the blood is several days and may be prolonged in cases of renal failure. The drug penetrates the placental barrier and into mother's milk. Excreted by the kidneys in small quantities, most of it is excreted in bile. Vitamin D3 has the property of cumulation.

How to take Aquadetrim drops correctly

The dosage of the drug is determined for each patient individually, taking into account his condition. The required amount of solution must be combined with 1 spoon of water.

In order to prevent rickets in healthy and full-term babies, from 28 days of life to 3 years, you can take 1-2 drops every day. Premature babies and twins are prescribed 3 drops every day. In summer, the dosage should be reduced to 1 drop per day.

Pregnant women are prescribed 1 drop per day throughout pregnancy or 2 drops from the 3rd trimester. Postmenopausal women can take 2 drops per day.

To treat rickets, the medication is prescribed to be taken every day, 6-10 drops for 30 days, taking into account the severity of the condition and the clinical picture. In addition, you regularly need to monitor the patient’s condition and maintain normal levels of calcium and phosphorus in the body.

In the first 5 days you need to take 4 drops per day. When the patient is sure that the drug is well tolerated by the body, the dosage can be gradually increased. With significant changes in bone tissue, the dose can reach its maximum value of 10 drops.

If necessary, you can take a break and resume the therapeutic course again, but only after examination by a specialist and his appointment. Treatment should continue until significant results are achieved. After this, you can switch to taking a prophylactic dose.

Aquadetrim drops for oral administration 15 thousand IU/ml 10 ml (Akrikhin)

Vitamin D3 is a natural form of vitamin D that is formed in humans in the skin under the influence of sunlight. Compared to vitamin D2, it is characterized by 25% higher activity. Vitamin D binds to the specific vitamin D receptor (VDR), which regulates the expression of many genes, including the ion channel genes TRPV6 (ensures the absorption of calcium in the intestine), CALB1 (calbindin; ensures the transport of calcium into the bloodstream), BGLAP (osteocalcin; ensures bone mineralization tissue and calcium homeostasis), SPP1 (osteopontin; regulates osteoclast migration), REN (renin; ensures regulation of blood pressure, being a key element of the renin-angiotensin-aldosterone regulation system), IGFBP (insulin-like growth factor binding protein; enhances the action of insulin-like growth factor) , FGF23 and FGFR23 (fibroblast growth factor 23; regulate the levels of calcium, phosphate anion, processes of cell division of fibroblasts), TGFB1 (transforming growth factor beta-1; regulates the processes of cell division and differentiation of osteocytes, chondrocytes, fibroblasts and keratinocytes), LRP2 ( LDL receptor-related protein 2; mediates endocytosis of low-density lipoproteins), INSR (insulin receptor; ensures the effects of insulin on any cell type). Vitamin D3 is an active antirachitic factor. The most important function of vitamin D3 is to regulate calcium and phosphate metabolism, which promotes proper mineralization and skeletal growth. Colecalciferol plays a significant role in the absorption of calcium and phosphates in the intestine, in the transport of mineral salts and in the process of bone calcification, and also regulates the excretion of calcium and phosphates by the kidneys. The concentration of calcium ions in the blood determines the maintenance of muscle tone of skeletal muscles, myocardial function, promotes nervous stimulation, and regulates the process of blood clotting. Lack of vitamin D in food, impaired absorption, calcium deficiency, as well as insufficient exposure to the sun during the period of rapid growth of a child leads to rickets, in adults - to osteomalacia, pregnant women may experience symptoms of tetany, disruption of the calcification processes of the bones of newborns. An increased need for vitamin D occurs in women during menopause, as they often develop osteoporosis due to hormonal imbalances. Vitamin D has a number of so-called. extraskeletal effects. Vitamin D is involved in the functioning of the immune system by modulating cytokine levels and regulating the division of T-helper lymphocytes and the differentiation of B-lymphocytes. A number of studies have noted a decrease in the incidence of respiratory tract infections when taking vitamin D. It has been shown that vitamin D is an important part of the homeostasis of the immune system: it prevents autoimmune diseases (type 1 diabetes, multiple sclerosis, rheumatoid arthritis, inflammatory bowel diseases, etc.) Vitamin D has antiproliferative and prodifferentiating effects, which determine the oncoprotective effect of vitamin D. It has been noted that the incidence of certain tumors (breast cancer, colon cancer) increases against the background of low levels of vitamin D in the blood. Vitamin D is involved in the regulation of carbohydrate and fat metabolism by influencing the synthesis of IRS1 (insulin receptor substrate 1; participates in the intracellular pathways of the insulin receptor signal), IGF (insulin-like growth factor; regulates the balance of adipose and muscle tissue), PPAR-δ (activated receptor peroxisome proliferators, type δ; helps process excess cholesterol). According to epidemiological studies, vitamin D deficiency is associated with the risk of metabolic disorders (metabolic syndrome and type 2 diabetes mellitus). Vitamin D receptors and metabolizing enzymes are expressed in arterial vessels, the heart, and virtually all cells and tissues relevant to the pathogenesis of cardiovascular disease. Animal models show anti-atherosclerotic effects, renin suppression and prevention of myocardial damage, etc. Low levels of vitamin D in humans are associated with unfavorable risk factors for cardiovascular pathology, such as diabetes mellitus, dyslipidemia, arterial hypertension, and are associated with the risk of cardiovascular accidents incl. strokes. Studies in experimental models of Alzheimer's disease showed that vitamin D3 reduced amyloid accumulation in the brain and improved cognitive function. Non-interventional human studies have shown that the incidence of dementia and Alzheimer's disease increases with low vitamin D levels and low dietary intake of vitamin D. Cognitive function and the incidence of Alzheimer's disease have been impaired with low vitamin D levels.

Contraindications and adverse reactions

Taking the drug is contraindicated in the following cases:

• excessive presence of calcium in the body;
• excess vitamin D;
• kidney diseases;
• urolithiasis;
• age up to 1 month;
• pulmonary tuberculosis;
• increased susceptibility to constituent elements.

The medicine should be used with caution by people who are immobilized, as well as during pregnancy and breastfeeding.

Excessive presence of vitamin D is manifested by the following symptoms: vomiting, nausea, lack of appetite, constipation, dry mouth, malaise, mental problems, weight loss, insomnia, high body temperature, high levels of calcium in the blood.

As soon as adverse reactions are detected, you should immediately stop taking the medication and, if possible, limit the intake of the mineral into the body. You also need to start taking vitamins A, B, C.

Allergies may also appear in the form of a skin rash.

If you constantly exceed the dose, an overdose may occur, which is manifested by increased adverse reactions. The most common symptoms are pain in the joints, muscles and head.