Genferon is in demand for the treatment of infections of the urogenital tract due to the convenience of the dosage form. Safety and ease of administration, lack of taste during use have made this medicine in demand among patients with viral diseases of the genitourinary system. Unfortunately, there are cases where suppositories did not have a therapeutic effect or, when administered, did not melt at human body temperature. Such phenomena are associated with improper storage.
Best before date
The expiration date of Genferon is necessarily printed on packaging: consumer cardboard and on each contour cell.
| Release form | Time before opening, number of years | Period after opening, number of years | Storage | Optimal temperature |
| Suppositories | 2 | 2 |
| +2…+8 °C |
If, when comparing calendar dates, it is clear that there are only 10 days left until the end of the period, the product can still be used, since expiration dates are set with some reserve. In this case, you can ask the pharmacist where exactly and how Genferon is stored in their pharmacy in order to identify temperature violations.
Genferon should be stored in the refrigerator. If the drug is left at elevated temperatures, the shelf life is sharply reduced, as the candles melt and the active substance decomposes.
As of December 2021, there is no data on rejected batches of the drug. If in doubt, it is recommended to call your local Roszdravnadzor office.
When purchasing a product, you need to check the integrity of the packaging: outer cardboard and inner cell. The manufacturer instructs not to use the product after the expiration date: the suppositories may become insoluble, which means the active substance will not enter the bloodstream.
GENFERON LIGHT 125000IU+5MG N10 SUPP VAGINAL/RECTAL
The drug can be used both vaginally and rectally. The route of administration, dose and course duration depend on age and the specific clinical situation. In adults and children over 7 years of age, Genferon® Light is used at a dose of 250,000 IU of interferon alfa-2b per suppository. In children under 7 years of age, including infants, it is safe to use the drug at a dose of 125,000 IU of interferon alfa-2b per suppository. In women who are 13–40 weeks pregnant, the drug is used at a dose of 250,000 IU of interferon alfa-2b per suppository.
Recommended doses and treatment regimens:
– Acute respiratory viral infections and other acute diseases of a viral nature in children:
1 suppository rectally 2 times a day with a 12-hour interval parallel to the main therapy for 5 days. If, after a 5-day treatment period, the symptoms of the disease do not decrease or become more pronounced, the patient should consult a doctor. According to clinical indications, it is possible to repeat the course of treatment after a 5-day interval.
– Acute respiratory viral infections in frequently and long-term ill children aged 3 to 6 years:
1 suppository (125,000 IU) rectally 2 times a day with an interval of 12 hours for 10 days parallel to standard therapy. After completing the main period of treatment for an acute respiratory viral infection, it is possible to switch to a prophylactic regimen: 1 suppository (125,000 IU) rectally 1 time at night, every other day for 3 weeks.
– Chronic infectious and inflammatory diseases of viral etiology in children over 7 years of age:
1 suppository (250,000 IU) rectally 2 times a day with a 12-hour interval parallel to standard therapy for 10 days. Then for 1-3 months - 1 suppository rectally at night every other day.
– Acute infectious and inflammatory diseases of the urogenital tract in children:
1 suppository rectally 2 times a day with a 12-hour interval for 10 days against the background of specific therapy prescribed and supervised by a doctor.
– Infectious and inflammatory diseases of the urogenital tract in pregnant women:
1 suppository (250,000 IU) vaginally 2 times a day with a 12-hour interval for 10 days against the background of specific therapy prescribed and supervised by a doctor.
– Infectious and inflammatory diseases of the urogenital tract in women:
1 suppository (250,000 IU) vaginally or rectally (depending on the nature of the disease) 2 times a day with a 12-hour interval for 10 days against the background of specific therapy prescribed and supervised by a doctor. For prolonged forms, 1 suppository 3 times a week, every other day, for 1–3 months.
How to store
To store Genferon, you need to use a refrigerator compartment with a temperature of +2 to +8 °C. Access for children should be limited, so the first aid kit should be locked.
The medication should not be left unattended at room, elevated or sub-zero temperatures: near heaters or in the freezer.
IMPORTANT. The manufacturer reports that due to improper storage - at sub-zero and room temperatures - suppositories can become unmeltable, which makes their use impossible. The same can be observed when trying to use expired candles.
There are no analogues of Genferon based on the complete coincidence of active ingredients. However, within the pharmacological group “Interferons in combinations” you can select a replacement:
- Kipferon;
- Herpferon;
- Giaferon;
- Mycoferon;
- Vagiferon.
Buy Genferon light vaginal/rectal suppositories 125t IU No. 10 in pharmacies
Genferon Light Buy Genferon Light in pharmacies
DOSAGE FORMS suppositories for vaginal or rectal administration 125000IU+5mg
MANUFACTURERS Biocad CJSC (Russia)
GROUP Antiviral - interferons
COMPOSITION Interferon alpha-2b, taurine.
INTERNATIONAL NON-PROPENTED NAME Interferon alpha-2b+Taurine
PHARMACOLOGICAL ACTION Has local and systemic effects. The drug contains recombinant human interferon alpha-2b. Interferon alpha-2b has antiviral, immunomodulatory, antiproliferative and antibacterial effects. The immunomodulatory effect is manifested, first of all, by enhancing cell-mediated reactions of the immune system, which increases the effectiveness of the immune response against viruses, intracellular parasites and cells that have undergone tumor transformation. Activation under the influence of interferon of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of pathological foci; in addition, due to the influence of interferon, restoration of the production of secretory immunoglobulin A is achieved. The antibacterial effect is mediated by reactions of the immune system, enhanced under the influence of interferon. Taurine helps normalize metabolic processes and tissue regeneration, has membrane-stabilizing and immunomodulatory effects. Taurine helps maintain the biological activity of interferon, enhancing the therapeutic effect of the drug. With rectal administration of the drug, high bioavailability of interferon is observed, and therefore both local and pronounced systemic immunomodulatory effects are achieved; when used intravaginally, due to the high concentration at the site of infection and fixation on the cells of the mucous membrane, a pronounced local antiviral, antiproliferative and antibacterial effect is achieved, while the systemic effect is insignificant due to the low absorption capacity of the vaginal mucosa. The maximum concentration of interferon in the blood serum is achieved 5 hours after administration of the drug. The main route of elimination of β-interferon is renal catabolism. The half-life is 12 hours, which necessitates the use of the drug 2 times a day.
INDICATIONS FOR USE For the treatment of infectious and inflammatory diseases of the urogenital tract in children and women, including pregnant women. As a component of complex therapy - for the treatment of other infectious diseases of viral etiology.
CONTRAINDICATIONS Individual intolerance to interferon and other substances included in the drug. With caution: Exacerbation of allergic and autoimmune diseases. Use during pregnancy and lactation: Clinical studies have proven the effectiveness and safety of using the drug in the second and third trimesters of pregnancy. The safety of using the drug in the first trimester of pregnancy has not been studied.
SIDE EFFECTS Local allergic reactions (itching and burning sensation in the vagina). These phenomena are reversible and disappear within 72 hours after cessation of administration. Continuation of treatment is possible after consultation with a doctor. Phenomena that occur with the use of all types of interferon alfa-2b may be observed, such as chills, fever, fatigue, loss of appetite, muscle and headaches, joint pain, sweating, as well as leukemia and thrombocytopenia. In these cases, it is recommended to consult your doctor to decide whether to discontinue the drug or reduce the dose.
INTERACTION The drug is most effective as a component of complex therapy. When combined with antibacterial, fungicidal and antiviral drugs, mutual potentiation of action is observed, which makes it possible to achieve a high total therapeutic effect
METHOD OF APPLICATION AND DOSAGE The drug can be used both vaginally and rectally. The method of administration, dosage and course duration depend on age, the specific clinical situation and are determined by the attending physician.
OVERDOSE In case of accidental simultaneous administration of more suppositories than prescribed by the doctor, further administration should be suspended for 24 hours, after which treatment can be resumed according to the prescribed regimen.
SPECIAL INSTRUCTIONS The drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving vehicles, machinery, etc.).
STORAGE CONDITIONS Store at a temperature of 2 to 8 degrees. C. Keep out of the reach of children.
Safety of use
The manufacturer does not officially recommend combining Genferon treatment with alcohol intake for the following reasons:
- Alcohol causes a number of negative phenomena in the body, for example, it inhibits the function of hematopoiesis and puts a strain on the liver and excretory system. The presence of ethanol in the blood can aggravate the course of the disease.
- Genferon is usually used in complex therapy, that is, other medications are also prescribed. Then you need to take into account not only their compatibility with each other, but also the increased toxic effect of alcohol on the body.
- Under the influence of alcohol, the antiviral effectiveness of Genferon may decrease.
There have been no cases of overdose with Genferon. If the patient has used more suppositories than required, the manufacturer recommends refraining from administering the next suppository for 24 hours.
There is no data on the incompatibility of the drug with other drugs.
Genferon is sold by prescription, its validity period from the date of discharge is 2 months.
Instructions for use GENFERON® (GENFERON)
A combined drug whose effect is determined by the components included in its composition. Has local and systemic effects.
The composition of the drug Genferon® includes recombinant human interferon alpha-2b, produced by a strain of the bacterium Escherichia coli, into which the human interferon alpha-2b gene was introduced using genetic engineering methods.
Interferon alpha-2b has antiviral, immunomodulatory, antiproliferative and antibacterial effects. The antiviral effect is mediated by the activation of a number of intracellular enzymes that inhibit viral replication. The immunomodulatory effect is manifested, first of all, by enhancing cell-mediated reactions of the immune system, which increases the effectiveness of the immune response against viruses, intracellular parasites and cells that have undergone tumor transformation. This is achieved through the activation of CD8+ T killer cells, NK cells (natural killer cells), increased differentiation of B lymphocytes and their production of antibodies, activation of the monocyte-macrophage system and phagocytosis, as well as increased expression of molecules of the major histocompatibility complex type I, which increases the likelihood recognition of infected cells by cells of the immune system. Activation under the influence of interferon of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of pathological foci; in addition, due to the influence of interferon, restoration of the production of secretory immunoglobulin A is achieved. The antibacterial effect is mediated by reactions of the immune system, enhanced under the influence of interferon.
Taurine helps normalize metabolic processes and tissue regeneration, has membrane-stabilizing and immunomodulatory effects. Being a strong antioxidant, taurine directly interacts with reactive oxygen species, the excessive accumulation of which contributes to the development of pathological processes. Taurine helps maintain the biological activity of interferon, enhancing the therapeutic effect of the drug. Benzocaine (anesthetic) is a local anesthetic. Reduces the permeability of the cell membrane to sodium ions, displaces calcium ions from receptors located on the inner surface of the membrane, and blocks the conduction of nerve impulses. Prevents the occurrence of pain impulses at the endings of sensory nerves and their conduction along nerve fibers. It has an exclusively local effect, without being absorbed into the systemic circulation.
